vemurafenib
komponim kimik
instancë e
type of chemical entity
nënklasë e
përdor
strukturë kimike
masa
489,073 dalton[3]
formula kimike
C₂₃H₁₈ClF₂N₃O₃S[3]
kanonikja SMILES
CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F[3]
active ingredient in
Zelboraf[24]
World Health Organisation international non-proprietary name
vemurafenib[2]
medical condition treated
hairy cell leukemia[25]
metastatic melanoma[25]
skin cancer[25]
Erdheim-Chester disease[25]
melanoma[25]
significant drug interaction
reagon fizikisht me
pregnancy category
Australian pregnancy category D
US pregnancy category D
LiverTox likelihood score
LiverTox toxicity likelihood category E*[28]
subjekti ka rol
antineoplastic[29]
protein kinase inhibitors[30]
xenobiotic-transporting ATPase inhibitor[30]
kategoria në Commons
Vemurafenib
Reference
- ^ Freebase Data Dumps, 28 tetor 2013
- ^ a b c d e ChEBI, 18 tetor 2016, anglisht, vemurafenib, 63637
- ^ a b c d e f PubChem, 18 tetor 2016, anglisht, 42611257, Vemurafenib
- ^ a b c d e f GPXBXXGIAQBQNI-UHFFFAOYSA-N, InChIKey
- ^ a b UniChem
- ^ Quora
- ^ Global Substance Registration System, 18 tetor 2016, anglisht, vemurafenib, 207SMY3FQT
- ^ DrugBank, anglisht, 17 nëntor 2015, 08881, Vemurafenib
- ^ Protein Data Bank, 18 tetor 2016, anglisht, 3OG7, 3OG7
- ^ Protein Data Bank, 18 tetor 2016, anglisht, 5HES, 5HES
- ^ Protein Data Bank, 18 tetor 2016, anglisht, 4RZV, 4RZV
- ^ OpenAlex, 26 janar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
- ^ ChEMBL, 18 tetor 2016, anglisht, VEMURAFENIB, CHEMBL1229517
- ^ BBC Things
- ^ ChEBI release 2020-09-01
- ^ inferred from InChIKey
- ^ CAS Common Chemistry, 8 prill 2021, https://commonchemistry.cas.org/detail?cas_rn=918504-65-1, GPXBXXGIAQBQNI-UHFFFAOYSA-N
- ^ InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28), International Chemical Identifier
- ^ IUPHAR/BPS Guide to PHARMACOLOGY, 18 tetor 2016, anglisht, 5893, vemurafenib
- ^ Hazardous Substances Data Bank, 10 maj 2021, 28 tetor 2019, Vemurafenib, 8143
- ^ ChemSpider, 18 tetor 2016, anglisht, 24747352, Vemurafenib
- ^ NDF-RT, 19 janar 2016, anglisht, VEMURAFENIB, N0000183250
- ^ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
- ^ RxNorm, 1147224, 14 shkurt 2018
- ^ a b c d e Drug Indications Extracted from FAERS, 2 tetor 2018
- ^ a b c A reference set of clinically relevant adverse drug-drug interactions, hypothetically
- ^ a b IUPHAR/BPS Guide to PHARMACOLOGY, 17 gusht 2016, 5893, anglisht
- ^ LiverTox, 8 prill 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Vemurafenib, 28 qershor 2018
- ^ a b Medical Subject Headings, 15 mars 2018, C551177
- ^ a b N0000183250, 5 mars 2018, NDF-RT