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Glycoprotein hormones, alpha polypeptide

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proteinë

External resources

UMLS CUI
C0017963[1]
PDB structure ID
1DZ7[2]
1E9J[2]
1FL7[2]
1HCN[2]
1HD4[2]
1HRP[2]
1QFW[2]
1XWD[2]
4AY9[2]
4MQW[2]
Ensembl protein ID
ENSP00000486024[3]
ENSP00000358595[4]
ENSP00000482232[5]
ENSP00000486666[6]
ENSP00000487300[7]
RefSeq Protein ID
NP_000726[8]
NP_001239312[8]
UniProt protein ID
P01215[9]
Microsoft Academic ID
2780181328
Freebase ID
/m/03d996t

instancë e

proteinë[9]

pjesë e

Cystine-knot cytokine[10]
glycoprotein hormone alpha chain[10]

found in taxon

Homo sapiens[9]

encoded by

CGA[9]

molecular function

protein binding[11][12][13]

metoda e përcaktimit: IPI

hormone activity[14][15][16][17]

metoda e përcaktimit: IEA, IMP, TAS

hormone activity[18][19][20]

metoda e përcaktimit: IEA, IMP

follicle-stimulating hormone activity[21][22]

metoda e përcaktimit: IDA

follicle-stimulating hormone activity[23][24][25]

metoda e përcaktimit: IBA, IDA

cell component

Golgi lumen[26]

metoda e përcaktimit: TAS

extracellular region[26][19][20]

metoda e përcaktimit: IEA, TAS

extracellular space[21][22]

metoda e përcaktimit: IDA

follicle-stimulating hormone complex[21][22]

metoda e përcaktimit: IDA

extracellular space[23][24][25]

metoda e përcaktimit: IBA, IDA

follicle-stimulating hormone complex[23][24][25]

metoda e përcaktimit: IBA, IDA

biological process

cell-cell signaling[14]

metoda e përcaktimit: TAS

peptide hormone processing[26]

metoda e përcaktimit: TAS

positive regulation of cell population proliferation[27]

metoda e përcaktimit: NAS

positive regulation of transcription by RNA polymerase II[27]

metoda e përcaktimit: NAS

signal transduction[14]

metoda e përcaktimit: TAS

positive regulation of cell migration[27]

metoda e përcaktimit: NAS

regulation of transcription by RNA polymerase II[26]

metoda e përcaktimit: TAS

regulation of signaling receptor activity[28]

metoda e përcaktimit: IEA

G protein-coupled receptor signaling pathway[29]

metoda e përcaktimit: TAS

G protein-coupled receptor signaling pathway[26][24]

metoda e përcaktimit: IDA, TAS

regulation of signaling receptor activity[24]

metoda e përcaktimit: IDA

positive regulation of steroid biosynthetic process[21]

metoda e përcaktimit: IDA

thyroid hormone generation[25]

metoda e përcaktimit: IBA

positive regulation of steroid biosynthetic process[23][25]

metoda e përcaktimit: IBA, IDA

Reference

  1. ^ UMLS 2023, 24 maj 2023, inferred by common MeSH mappings on source and on Wikidata
  2. ^ a b c d e f g h i j P01215, 9 gusht 2016, anglisht, UniProt
  3. ^ Ensembl Release 99, ENSP00000486024
  4. ^ Ensembl Release 99, ENSP00000358595
  5. ^ Ensembl Release 99, ENSP00000482232
  6. ^ Ensembl Release 99, ENSP00000486666
  7. ^ Ensembl Release 99, ENSP00000487300
  8. ^ a b NCBI Gene, 30 maj 2020, 1081
  9. ^ a b c d UniProt, 13 nëntor 2019, P01215
  10. ^ a b InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P01215
  11. ^ IntAct protein interaction database, 8 prill 2019, Structure of human follicle-stimulating hormone in complex with its receptor, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215
  12. ^ IntAct protein interaction database, 8 prill 2019, Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215
  13. ^ IntAct protein interaction database, 8 prill 2019, Three-dimensional structure of human follicle-stimulating hormone, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215
  14. ^ a b c Proteome Inc., 31 tetor 2017, Isolation, cloning and sequence analysis of the cDNA for the α-subunit of human chorionic gonadotropin, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01215&geneProductId=UniProtKB:P01215
  15. ^ AgBase, 31 tetor 2017, Molecular biology of channel catfish gonadotropin receptors: 1. Cloning of a functional luteinizing hormone receptor and preovulatory induction of gene expression, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01215&geneProductId=UniProtKB:P01215
  16. ^ GOA, 31 tetor 2017, P01215, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01215&geneProductId=UniProtKB:P01215, IEA
  17. ^ InterPro, 31 tetor 2017, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01215&geneProductId=UniProtKB:P01215
  18. ^ AgBase, 8 prill 2019, Molecular biology of channel catfish gonadotropin receptors: 1. Cloning of a functional luteinizing hormone receptor and preovulatory induction of gene expression, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215
  19. ^ a b GOA, 8 prill 2019, P01215, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215, IEA
  20. ^ a b InterPro, 8 prill 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215
  21. ^ a b c d Expression of biologically active human follitropin in Chinese hamster ovary cells, GOA, 1 janar 2018, P01215, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215, IDA
  22. ^ a b c Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer, GOA, 1 janar 2018, P01215, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215, IDA
  23. ^ a b c d Expression of biologically active human follitropin in Chinese hamster ovary cells, GOA, 8 prill 2019, P01215, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215, IDA
  24. ^ a b c d e Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer, GOA, 8 prill 2019, P01215, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215, IDA
  25. ^ a b c d e GO Central, 8 prill 2019, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA, IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215
  26. ^ a b c d e Reactome, 8 prill 2019, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215
  27. ^ a b c British Heart Foundation, 8 prill 2019, Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01215
  28. ^ Gene Ontology Consortium, 31 tetor 2017, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01215&geneProductId=UniProtKB:P01215
  29. ^ Reactome, 31 tetor 2017, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01215&geneProductId=UniProtKB:P01215
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