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Interleukin 6

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proteinë

External resources

Freebase ID
/m/05gpxj[1]
RefSeq Protein ID
NP_000591[2]
NP_001305024[2]
XP_005249802[2]
XP_011513692[2]
NP_001358025[2]
PDB structure ID
4O9H[3]
1ALU[3]
1IL6[3]
1P9M[3]
2IL6[3]
4CNI[3]
4J4L[3]
4NI7[3]
4NI9[3]
4ZS7[3]
Ensembl protein ID
ENSP00000385675[4]
ENSP00000258743[5]
ENSP00000384928[6]
ENSP00000385043[7]
ENSP00000385227[8]
ENSP00000385718[9]
ENSP00000405150[10]
Microsoft Academic ID
11988809
UniProt protein ID
P05231[11]
BNCF Thesaurus ID
73989
OpenAlex ID
C11988809[12]

instancë e

proteinë[11]

pjesë e

interleukin-6[13]
four-helical cytokine-like, core[13]
Interleukin-6/GCSF/MGF, conserved site, protein family[14]

found in taxon

Homo sapiens[11]

encoded by

IL6[11]

molecular function

cytokine activity[15][16][17][18][19][20]

metoda e përcaktimit: NAS, IDA, ISS, IEA

growth factor activity[21][17][22][23]

metoda e përcaktimit: IDA, IEA, TAS

interleukin-6 receptor binding[24][25][26][18]

metoda e përcaktimit: NAS, IEA, TAS, IPI

protein binding[27][28][29][30][31]

metoda e përcaktimit: IPI

cell component

extracellular region[32][17][18]

metoda e përcaktimit: IEA, TAS

interleukin-6 receptor complex[22][33]

metoda e përcaktimit: IDA

extracellular space[17][34][35][20]

metoda e përcaktimit: IDA, IEA

endoplasmic reticulum lumen[32]

metoda e përcaktimit: TAS

biological process

regulation of angiogenesis[36]

metoda e përcaktimit: IC

positive regulation of translation[37]

metoda e përcaktimit: IDA

platelet activation[38]

metoda e përcaktimit: TAS

humoral immune response[39]

metoda e përcaktimit: IC

defense response to virus[20]

metoda e përcaktimit: IDA

response to peptidoglycan[40]

metoda e përcaktimit: NAS

neuron projection development[41]

metoda e përcaktimit: IMP

defense response to Gram-positive bacterium[42]

metoda e përcaktimit: TAS

negative regulation of fat cell differentiation[43]

metoda e përcaktimit: NAS

positive regulation of peptidyl-serine phosphorylation[44]

metoda e përcaktimit: IDA

positive regulation of leukocyte chemotaxis[42]

metoda e përcaktimit: TAS

positive regulation of T cell proliferation[45]

metoda e përcaktimit: IDA

positive regulation of interleukin-6 production[46]

metoda e përcaktimit: IDA

positive regulation of peptidyl-tyrosine phosphorylation[44]

metoda e përcaktimit: IDA

positive regulation of acute inflammatory response[47]

metoda e përcaktimit: IDA

inflammatory response[35]

metoda e përcaktimit: IDA

negative regulation of collagen biosynthetic process[48]

metoda e përcaktimit: IDA

positive regulation of MAPK cascade[44][48]

metoda e përcaktimit: IDA

hepatic immune response[49][47]

metoda e përcaktimit: IDA, TAS

monocyte chemotaxis[50]

metoda e përcaktimit: IC

positive regulation of DNA-binding transcription factor activity[51]

metoda e përcaktimit: IDA

negative regulation of apoptotic process[52]

metoda e përcaktimit: IDA

positive regulation of osteoblast differentiation[53]

metoda e përcaktimit: TAS

positive regulation of NF-kappaB transcription factor activity[48]

metoda e përcaktimit: IDA

acute-phase response[49][17]

metoda e përcaktimit: IEA, TAS

immune response[18]

metoda e përcaktimit: IEA

regulation of vascular endothelial growth factor production[54]

metoda e përcaktimit: IDA

positive regulation of chemokine production[40][46]

metoda e përcaktimit: NAS, IDA

negative regulation of lipid storage[43]

metoda e përcaktimit: NAS

neutrophil mediated immunity[42]

metoda e përcaktimit: TAS

positive regulation of smooth muscle cell proliferation[46]

metoda e përcaktimit: IDA

positive regulation of type B pancreatic cell apoptotic process[55]

metoda e përcaktimit: TAS

response to glucocorticoid[35]

metoda e përcaktimit: IDA

defense response to Gram-negative bacterium[42]

metoda e përcaktimit: TAS

positive regulation of cell population proliferation[56][22]

metoda e përcaktimit: IDA, IMP

positive regulation of apoptotic process[57]

metoda e përcaktimit: IDA

positive regulation of B cell activation[19]

metoda e përcaktimit: IDA

post-translational protein modification[32]

metoda e përcaktimit: TAS

regulation of signaling receptor activity[58]

metoda e përcaktimit: IEA

positive regulation of tyrosine phosphorylation of STAT protein[23][59]

metoda e përcaktimit: IDA

neutrophil apoptotic process[52]

metoda e përcaktimit: IDA

negative regulation of cell population proliferation[60]

metoda e përcaktimit: TAS

positive regulation of gene expression[59]

metoda e përcaktimit: IDA

endocrine pancreas development[16]

metoda e përcaktimit: ISS

negative regulation of bone resorption[16]

metoda e përcaktimit: ISS

positive regulation of transcription, DNA-templated[61][62][51]

metoda e përcaktimit: IDA, IMP

positive regulation of transcription by RNA polymerase II[16][44][63][64]

metoda e përcaktimit: IDA, ISS

glucagon secretion[16]

metoda e përcaktimit: ISS

cellular response to hydrogen peroxide[65]

metoda e përcaktimit: IDA

cellular response to lipopolysaccharide[66]

metoda e përcaktimit: IMP

T-helper 17 cell lineage commitment[67]

metoda e përcaktimit: ISS

positive regulation of T-helper 2 cell cytokine production[16]

metoda e përcaktimit: ISS

negative regulation of interleukin-1-mediated signaling pathway[16]

metoda e përcaktimit: ISS

cytokine-mediated signaling pathway[32][22][23]

metoda e përcaktimit: IDA, TAS

interleukin-6-mediated signaling pathway[32][63][68]

metoda e përcaktimit: IDA, TAS

positive regulation of receptor signaling pathway via JAK-STAT[64][48][68][69]

metoda e përcaktimit: IC, IDA

përputhje e saktë

http://purl.uniprot.org/uniprot/P05231[70]

ka pjesë

Interleukin-6/GCSF/MGF, conserved site[13]

Reference

  1. ^ Freebase Data Dumps, 28 tetor 2013
  2. ^ a b c d e NCBI Gene, 30 maj 2020, 3569
  3. ^ a b c d e f g h i j P05231, 9 gusht 2016, UniProt, anglisht
  4. ^ Ensembl Release 99, ENSP00000385675
  5. ^ Ensembl Release 99, ENSP00000258743
  6. ^ Ensembl Release 99, ENSP00000384928
  7. ^ Ensembl Release 99, ENSP00000385043
  8. ^ Ensembl Release 99, ENSP00000385227
  9. ^ Ensembl Release 99, ENSP00000385718
  10. ^ Ensembl Release 99, ENSP00000405150
  11. ^ a b c d UniProt, 13 nëntor 2019, P05231
  12. ^ OpenAlex, 26 janar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  13. ^ a b c InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P05231
  14. ^ inferred from protein domain or family
  15. ^ NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA
  16. ^ a b c d e f g ISS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, GOA
  17. ^ a b c d e IEA, 27 mars 2018, P05231, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  18. ^ a b c d IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, InterPro, GOA
  19. ^ a b IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA
  20. ^ a b c IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA
  21. ^ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, Proteome Inc., Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6), GOA
  22. ^ a b c d IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Molecular cloning and expression of an IL-6 signal transducer, gp130, GOA
  23. ^ a b c IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF, GOA
  24. ^ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, Proteome Inc., Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production, GOA
  25. ^ NAS, 27 mars 2018, P05231, Marked cell-type-specific differences in glycosylation of human interleukin-6, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  26. ^ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
  27. ^ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, IntAct protein interaction database, Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network, GOA
  28. ^ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, IntAct protein interaction database, Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling, GOA
  29. ^ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, IntAct protein interaction database, A human protein-protein interaction network: a resource for annotating the proteome, GOA
  30. ^ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, IntAct protein interaction database, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
  31. ^ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, IntAct protein interaction database, Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex, GOA
  32. ^ a b c d e TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, Reactome, GOA
  33. ^ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
  34. ^ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
  35. ^ a b c IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA
  36. ^ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA
  37. ^ IDA, 27 mars 2018, P05231, BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  38. ^ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism, GOA
  39. ^ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA
  40. ^ a b NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
  41. ^ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6, GOA
  42. ^ a b c d TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
  43. ^ a b NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes, GOA
  44. ^ a b c d IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, Mouse Genome Informatics, Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells, GOA
  45. ^ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Synergistic activation of human T cells by interleukin 1 and interleukin 6, GOA
  46. ^ a b c IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA
  47. ^ a b IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells, GOA
  48. ^ a b c d IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression, GOA
  49. ^ a b TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE), GOA
  50. ^ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA
  51. ^ a b IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells, GOA
  52. ^ a b IDA, 27 mars 2018, P05231, Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  53. ^ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells, GOA
  54. ^ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA
  55. ^ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA
  56. ^ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA
  57. ^ IDA, 27 mars 2018, P05231, Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  58. ^ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, Gene Ontology Consortium, GOA
  59. ^ a b IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway, GOA
  60. ^ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, Proteome Inc., Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA
  61. ^ IMP, 27 mars 2018, P05231, Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  62. ^ IDA, 27 mars 2018, P05231, B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  63. ^ a b IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation, GOA
  64. ^ a b IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA
  65. ^ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins, GOA
  66. ^ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, Mouse Genome Informatics, SASH1 is a scaffold molecule in endothelial TLR4 signaling, GOA
  67. ^ ISS, 27 mars 2018, P05231, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
  68. ^ a b IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2, GOA
  69. ^ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, 27 mars 2018, British Heart Foundation, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA
  70. ^ Identifiers.org
Marrë nga "https://sq.wikipedia.org/wiki/Speciale:AboutTopic/Q412889"