Actin related protein 3

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proteinë

External resources

PDB structure ID	2P9N^[1] 1TYQ^[1] 1U2V^[1] 4JD2^[1] 3DXK^[1] 3UKU^[1] 3UKR^[1] 2P9P^[1] 2P9K^[1] 2P9U^[1] 3ULE^[1] 3RSE^[1] 2P9S^[1] 2P9I^[1] 4XF2^[1] 2P9L^[1] 1K8K^[1] 3DXM^[1] 4XEI^[1]
Ensembl protein ID	ENSP00000263238^[2] ENSP00000394213^[3] ENSP00000403125^[4] ENSP00000407912^[5] ENSP00000444987^[6]
RefSeq Protein ID	NP_001264069^[7] NP_005712^[7]
UniProt protein ID	P61158^[8]
Freebase ID	/m/03cv_zs

instancë e

proteinë^[8]

pjesë e

Actin-related protein 3^[9]

membrane protein^[10]

Actin/actin-like conserved site, protein family^[11]

found in taxon

Homo sapiens^[8]

encoded by

ACTR3^[8]

molecular function

structural constituent of cytoskeleton^[12]

metoda e përcaktimit: IDA

nucleotide binding^[13]

metoda e përcaktimit: IEA

actin binding^[13]

metoda e përcaktimit: IEA

actin filament binding^[12]

metoda e përcaktimit: IDA

ATP binding^[13]^[14]

metoda e përcaktimit: IEA

protein binding^[15]

metoda e përcaktimit: IPI

cell component

extracellular exosome^[16]^[17]^[18]^[19]

metoda e përcaktimit: IDA

brush border^[20]

metoda e përcaktimit: IEA

actin cytoskeleton^[21]

metoda e përcaktimit: TAS

Citoplazma^[13]

metoda e përcaktimit: IEA

cell projection^[13]

metoda e përcaktimit: IEA

cytosol^[22]

metoda e përcaktimit: TAS

lamellipodium^[20]

metoda e përcaktimit: IEA

cell-cell junction^[20]

metoda e përcaktimit: IEA

membrane^[23]

metoda e përcaktimit: IDA

focal adhesion^[24]

metoda e përcaktimit: IDA

cytoskeleton^[13]

metoda e përcaktimit: IEA

arp2/3 protein complex^[21]^[14]^[12]

metoda e përcaktimit: IDA, IEA, TAS

biological process

Fc-gamma receptor signaling pathway involved in phagocytosis^[22]

metoda e përcaktimit: TAS

ephrin receptor signaling pathway^[22]

metoda e përcaktimit: TAS

cilium assembly^[25]

metoda e përcaktimit: IMP

Arp2/3 complex-mediated actin nucleation^[14]^[12]

metoda e përcaktimit: IDA, IEA

Mejoza^[20]

metoda e përcaktimit: IEA

spindle localization^[20]

metoda e përcaktimit: IEA

asymmetric cell division^[20]

metoda e përcaktimit: IEA

actin filament organization^[14]

metoda e përcaktimit: IEA

cell projection organization^[13]

metoda e përcaktimit: IEA

meiotic chromosome movement towards spindle pole^[20]

metoda e përcaktimit: IEA

establishment or maintenance of cell polarity^[20]

metoda e përcaktimit: IEA

meiotic cytokinesis^[20]

metoda e përcaktimit: IEA

membrane organization^[22]

metoda e përcaktimit: TAS

ka pjesë

Actin/actin-like conserved site^[9]

kategoria në Commons

ACTR3

Reference

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s P61158, 9 gusht 2016, UniProt, anglisht
^ Ensembl Release 99, ENSP00000263238
^ Ensembl Release 99, ENSP00000394213
^ Ensembl Release 99, ENSP00000403125
^ Ensembl Release 99, ENSP00000407912
^ Ensembl Release 99, ENSP00000444987
^ ^a ^b NCBI Gene, 30 maj 2020, 10096
^ ^a ^b ^c ^d UniProt, 13 nëntor 2019, P61158
^ ^a ^b InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P61158
^ inferred from GOA cell component → membrane
^ inferred from protein domain or family
^ ^a ^b ^c ^d IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, FlyBase, Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity, GOA
^ ^a ^b ^c ^d ^e ^f ^g IEA, 26 shtator 2017, P61158, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt
^ ^a ^b ^c ^d IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, InterPro, GOA
^ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, IntAct protein interaction database, A comprehensive resource of interacting protein regions for refining human transcription factor networks, GOA
^ IDA, 26 shtator 2017, P61158, Proteomic analysis of podocyte exosome-enriched fraction from normal human urine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt
^ IDA, 26 shtator 2017, P61158, Large-scale proteomics and phosphoproteomics of urinary exosomes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt
^ IDA, 26 shtator 2017, P61158, In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt
^ IDA, 26 shtator 2017, P61158, MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, Ensembl genome database project, GOA
^ ^a ^b TAS, 26 shtator 2017, P61158, The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt
^ ^a ^b ^c ^d TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, Reactome, GOA
^ IDA, 26 shtator 2017, P61158, Defining the membrane proteome of NK cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt
^ IDA, 26 shtator 2017, P61158, Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt
^ IMP, 26 shtator 2017, P61158, Functional genomic screen for modulators of ciliogenesis and cilium length, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[r41c1d36c-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s P61158, 9 gusht 2016, UniProt, anglisht

[rf1148c39-2] Ensembl Release 99, ENSP00000263238

[r089aa6ab-3] Ensembl Release 99, ENSP00000394213

[r154dbd80-4] Ensembl Release 99, ENSP00000403125

[r29799b6f-5] Ensembl Release 99, ENSP00000407912

[r8488f4d6-6] Ensembl Release 99, ENSP00000444987

[redd4df98-7] NCBI Gene, 30 maj 2020, 10096

[r7574376c-8] UniProt, 13 nëntor 2019, P61158

[r569e2d97-9] InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P61158

[r24044355-10] rred from GOA cell component → membrane

[r90e8ab8e-11] rred from protein domain or family

[rfb40e91e-12] IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, FlyBase, Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity, GOA

[r257aec80-13] ^ ^a ^b ^c ^d ^e ^f ^g IEA, 26 shtator 2017, P61158, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[rbc30471c-14] IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, InterPro, GOA

[r5e2de2a7-15] IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, IntAct protein interaction database, A comprehensive resource of interacting protein regions for refining human transcription factor networks, GOA

[r985f8469-16] IDA, 26 shtator 2017, P61158, Proteomic analysis of podocyte exosome-enriched fraction from normal human urine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[r4e9e514c-17] IDA, 26 shtator 2017, P61158, Large-scale proteomics and phosphoproteomics of urinary exosomes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[r51587b80-18] IDA, 26 shtator 2017, P61158, In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[rc65c291b-19] IDA, 26 shtator 2017, P61158, MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[r3a623db9-20] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, Ensembl genome database project, GOA

[rf0634d04-21] TAS, 26 shtator 2017, P61158, The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[rf033758c-22] TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, 26 shtator 2017, Reactome, GOA

[r2b67df76-23] IDA, 26 shtator 2017, P61158, Defining the membrane proteome of NK cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[rd3549d36-24] IDA, 26 shtator 2017, P61158, Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

[r6dbc29f7-25] IMP, 26 shtator 2017, P61158, Functional genomic screen for modulators of ciliogenesis and cilium length, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61158&geneProductId=UniProtKB:P61158, UniProt

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