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komponim kimik

External resources

numri CAS
MeSH descriptor ID
D009543

referuar si: Nifedipine

LiverTox ID
MeSH concept ID
NSC number
ChEMBL ID
Human Metabolome Database ID
WordNet 3.1 Synset ID
03829554-n[5]
AICS Chemical ID (BEING DELETED)
ECHA Substance Infocard ID
DrugCentral ID
CAMEO Chemicals ID
Probes And Drugs ID
NDF-RT ID
Freebase ID
CA PROP 65 ID
Reaxys registry number
497773[10]
PubChem CID
UniChem compound ID
YSO ID
27988[12]

referuar si: nifedipiini, nifedipin, nifedipine

PDB ligand ID
SPLASH
KEGG ID
OpenAlex ID
KBpedia ID
InChIKey
DrugBank ID
ChEBI ID
7565[2][16]

mapping relation type: përputhje e përpiktë

DSSTox substance ID
SureChEMBL ID
UNII
HSDB ID
kodi ATC
Microsoft Academic ID
WikiProjectMed ID
DSSTOX compound identifier
MedlinePlus drug identifier
UMLS CUI
electronic Essential Medicines List medicine ID
ChemSpider ID
numri CE
244-598-3[1]
MeSH tree code
Guide to Pharmacology Ligand ID
InChI
RxNorm ID

instancë e

type of chemical entity

nënklasë e

dihydropyridine[22]

përdor

strukturë kimike

masa

346,116486 dalton[24]

formula kimike

C₁₇H₁₈N₂O₆[11]

kanonikja SMILES

CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC[11]

defined daily dose

30 milligram[25]

route of administration: oral administration

30 milligram[25]

route of administration: parenteral route of administration

active ingredient in

Procardia[26]
Adalat[27]
Afeditab CR[28]
Nifedical[29]
Nifediac[30]

World Health Organisation international non-proprietary name

nifedipine[10]

found in taxon

significant drug interaction

doxazosin[34]

side effect: Hipotensioni

itraconazole[35]

side effect: sinus bradycardia

itraconazole[35]

side effect: Hipotensioni

itraconazole[35]

side effect: acute kidney injury

posaconazole[35]

side effect: sinus bradycardia

posaconazole[35]

side effect: Hipotensioni

posaconazole[35]

side effect: acute kidney injury

voriconazole[35]

side effect: sinus bradycardia

voriconazole[35]

side effect: Hipotensioni

voriconazole[35]

side effect: acute kidney injury

ritonavir[35]

side effect: sinus bradycardia

ritonavir[35]

side effect: Hipotensioni

ritonavir[35]

side effect: acute kidney injury

clarithromycin[35]

side effect: sinus bradycardia

clarithromycin[35]

side effect: Hipotensioni

clarithromycin[35]

side effect: acute kidney injury

cobicistat[35]

side effect: sinus bradycardia

cobicistat[35]

side effect: Hipotensioni

cobicistat[35]

side effect: acute kidney injury

Ketoconazole[35]

side effect: sinus bradycardia

Ketoconazole[35]

side effect: Hipotensioni

Ketoconazole[35]

side effect: acute kidney injury

cimetidine[34]

side effect: Hipotensioni

cimetidine[34]

side effect: headache disorder

cimetidine[34]

side effect: tachycardia

cimetidine[34]

side effect: peripheral edema

reagon fizikisht me

Calcium voltage-gated channel subunit alpha1 S[36]
Calcium voltage-gated channel subunit alpha1 C[36]
Calcium voltage-gated channel subunit alpha1 D[36]
Calcium voltage-gated channel subunit alpha1 F[36]
Glycine receptor alpha 1[36]
Glycine receptor alpha 3[36]
Glycine receptor beta[36]
Potassium voltage-gated channel, shaker-related subfamily, member 1[36]
Potassium voltage-gated channel subfamily A member 5[36]
Potassium voltage-gated channel, shaker-related subfamily, member 7[36]
Potassium voltage gated channel, Shaw-related subfamily, member 1[36]
nuclear receptor subfamily 1 group I member 2[36]
Transient receptor potential cation channel subfamily M member 3[36]

legal status (medicine)

boxed warning[37]

LiverTox likelihood score

LiverTox toxicity likelihood category B[38]

subjekti ka rol

calcium channel blocker[39][40]
vasodilator agent[40]
tocolytic uterine relaxants[40]
developmental toxicant[41]

koha e fillimit: 29 janar 1999

male reproductive toxicant[41]

koha e fillimit: 29 janar 1999

female reproductive toxicant[41]

koha e fillimit: 29 janar 1999

essential medicine

stylized name

NIFEdipine[42]

ka veçori: Tall Man lettering

lëshuar nga: Food and Drug Administration

referuar si: Nifedipine

MCN code

2933.39.43

kategoria në Commons

Nifedipine

Reference

  1. ^ a b c d e f Global Substance Registration System, 19 nëntor 2016, anglisht, nifedipine, I9ZF7L6G2L
  2. ^ a b ChEMBL, 19 nëntor 2016, anglisht, NIFEDIPINE, CHEMBL193
  3. ^ a b inferred from InChIKey
  4. ^ a b c d e f HYIMSNHJOBLJNT-UHFFFAOYSA-N, InChIKey
  5. ^ GF WordNet
  6. ^ ECHA Substance Infocard database, 27 dhjetor 2018, 100.040.529, Nifedipine, CAS no.: 21829-25-4
  7. ^ a b UniChem
  8. ^ Freebase Data Dumps, 28 tetor 2013
  9. ^ California Proposition 65 list of chemicals, 6 janar 2020, https://oehha.ca.gov/chemicals/nifedipine
  10. ^ a b c d ChEBI, 3 tetor 2016, anglisht, nifedipine, 7565
  11. ^ a b c d e PubChem, 19 nëntor 2016, anglisht, 4485, nifedipine
  12. ^ YSO-Wikidata mapping project, 7 shkurt 2022
  13. ^ OpenAlex, 26 janar 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  14. ^ KBpedia, 9 korrik 2020
  15. ^ ChEBI release 2020-09-01
  16. ^ International Chemical Identifier, InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
  17. ^ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
  18. ^ Hazardous Substances Data Bank, 10 maj 2021, 28 tetor 2019, Nifedipine, 7775
  19. ^ DrugBank, anglisht, 17 nëntor 2015, 01115, Nifedipine
  20. ^ ChemSpider, 19 nëntor 2016, anglisht, 4330, Nifedipine
  21. ^ IUPHAR/BPS Guide to PHARMACOLOGY, 19 nëntor 2016, anglisht, 2514, nifedipine
  22. ^ N0000146717, 27 shkurt 2018, NDF-RT
  23. ^ alkaloid
  24. ^ PubChem, 3 tetor 2016, anglisht, 4485, nifedipine
  25. ^ a b https://www.whocc.no/atc_ddd_index/?code=C08CA05
  26. ^ RxNorm, 203423, 14 shkurt 2018
  27. ^ RxNorm, 151131, 14 shkurt 2018
  28. ^ RxNorm, 542720, 14 shkurt 2018
  29. ^ RxNorm, 491311, 14 shkurt 2018
  30. ^ RxNorm, 541600, 14 shkurt 2018
  31. ^ A community-driven global reconstruction of human metabolism.
  32. ^ a b N0000146717, 13 dhjetor 2016, NDF-RT, anglisht
  33. ^ Drug Indications Extracted from FAERS, 2 tetor 2018
  34. ^ a b c d e A reference set of clinically relevant adverse drug-drug interactions, probably
  35. ^ a b c d e f g h i j k l m n o p q r s t u A reference set of clinically relevant adverse drug-drug interactions, established
  36. ^ a b c d e f g h i j k l m IUPHAR/BPS Guide to PHARMACOLOGY, 17 gusht 2016, 2514, anglisht
  37. ^ FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links., https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
  38. ^ LiverTox, 8 prill 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Nifedipine, 11 janar 2017
  39. ^ N0000146717, 5 mars 2018, NDF-RT
  40. ^ a b c Medical Subject Headings, 15 mars 2018, D009543
  41. ^ a b c California Proposition 65 list of chemicals, 18 mars 2020, https://oehha.ca.gov/chemicals/nifedipine
  42. ^ https://www.fda.gov/drugs/medication-errors-related-cder-regulated-drug-products/fda-name-differentiation-project, 2 shtator 2022